SCHEDULED MAINTENANCE
Chiral-diamine catalyzed addition of ZnMe2 to PhC(O)CF2X (in dichloromethane at −30 °C) affords fluorinated alkyl tertiary alcohols in high yield (quantitative for X = H, F, Cl; 84% for X = CF3) and up to 99% ee. These conditions are similarly very efficient for other various ArC(O)CF3 molecules. A fine analysis of the results can be performed based on a double-cycle mechanism.
T. Neves-Garcia, A. Vélez, J. M. Martínez-Ilarduya and P. Espinet, Chem. Commun., 2018, 54, 11809 DOI: 10.1039/C8CC06358C
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