Issue 76, 2018
From the journal:

Chemical Communications

A novel mass spectrometry method based on competitive non-covalent interaction for the detection of biomarkers†

Jing Han,ab   Yafeng Li,a   Lingpeng Zhan,a   Jinjuan Xue,a   Jie Sun,a   Caiqiao Xiong*a  and  Zongxiu Nie ORCID logo *abc  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
E-mail: xiongcq@iccas.ac.cn, znie@iccas.ac.cn

b University of the Chinese Academy of Sciences, Beijing, China

c National Center for Mass Spectrometry in Beijing, Beijing, China

Abstract

We report a novel biosensor platform based on competitive non-covalent interaction between ssDNA and a mass tag towards AuNPs, which detects PSA biomarkers sensitively, observed using MALDI MS. A detection limit of 57 pg mL−1 has been achieved, showing an improvement of two orders of magnitude compared to the traditional spectroscopic method.

Graphical abstract: A novel mass spectrometry method based on competitive non-covalent interaction for the detection of biomarkers

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Article information

DOI
https://doi.org/10.1039/C8CC06100A
Article type
Communication
Submitted
27 Jul 2018
Accepted
17 Aug 2018
First published
18 Aug 2018

Chem. Commun., 2018,54, 10726-10729

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A novel mass spectrometry method based on competitive non-covalent interaction for the detection of biomarkers

J. Han, Y. Li, L. Zhan, J. Xue, J. Sun, C. Xiong and Z. Nie, Chem. Commun., 2018, 54, 10726 DOI: 10.1039/C8CC06100A

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