Internalization of the pseudorabies virus via macropinocytosis analyzed by quantum dot-based single-virus tracking

Cheng Lv; Yi Lin; En-Ze Sun; Bo Tang; Jian Ao; Jia-Jia Wang; Zhi-Ling Zhang; Zhenhua Zheng; Hanzhong Wang; Dai-Wen Pang

doi:10.1039/C8CC05614E

Internalization of the pseudorabies virus via macropinocytosis analyzed by quantum dot-based single-virus tracking†

Cheng Lv,^a Yi Lin,^a En-Ze Sun,^a Bo Tang,^a Jian Ao,^a Jia-Jia Wang,^a Zhi-Ling Zhang,

^a Zhenhua Zheng,^b Hanzhong Wang

^b and Dai-Wen Pang

*^a

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* Corresponding authors

^a Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, State Key Laboratory of Virology, The Institute for Advanced Studies, and Wuhan Institute of Biotechnology, Wuhan University, Wuhan, People's Republic of China
E-mail: dwpang@whu.edu.cn

^b State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, People's Republic of China

Abstract

With the aid of the single-virus tracking technique and the quantum dot-labeling strategy, the internalization of the pseudorabies virus (PrV) has been visualized in real time. The results demonstrate that macropinocytosis can be considered as a major pathway for PrV entering HeLa cells, which facilitates the development of therapeutics for virus-triggered diseases.

Chemical Communications

Internalization of the pseudorabies virus via macropinocytosis analyzed by quantum dot-based single-virus tracking†

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Internalization of the pseudorabies virus via macropinocytosis analyzed by quantum dot-based single-virus tracking

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