The bis(trifluoromethane)sulfonimide (Tf2NH) catalyzed intramolecular hydroamidation of terminal alkynes is reported. The combination of Et3SiH and Tf2NH provides cis-1,3-disubstituted isoindolines and sultams in high yield (up to 98%) and high diastereoselectivity (up to 99 : 1 d.r.).
Y. Tao and S. R. Gilbertson, Chem. Commun., 2018, 54, 11292 DOI: 10.1039/C8CC04946G
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