Issue 61, 2018
From the journal:

Chemical Communications

Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides†

Rintaro Iwata Hara, ORCID logo ab   Yusuke Maeda,a   Haruna Fujimakic  and  Takeshi Wada ORCID logo *a  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan
E-mail: twada@rs.tus.ac.jp

b Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan

c Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan

Abstract

This study assessed the effects of artificial cationic oligopeptides on a DNA/RNA hybrid duplex. An oligopeptide containing the octamer of L-2,4-diaminobutyric acid (Dab8) was found to enhance both the RNase A resistance and RNase H activity of the DNA/RNA hybrid, which are important for developing nucleic acid drugs.

Graphical abstract: Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides

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Article information

DOI
https://doi.org/10.1039/C8CC04082F
Article type
Communication
Submitted
22 May 2018
Accepted
05 Jul 2018
First published
06 Jul 2018

Chem. Commun., 2018,54, 8526-8529

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Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides

R. I. Hara, Y. Maeda, H. Fujimaki and T. Wada, Chem. Commun., 2018, 54, 8526 DOI: 10.1039/C8CC04082F

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