Issue 62, 2018
From the journal:

Chemical Communications

ALKBH5-induced demethylation of mono- and dimethylated adenosine†

Timm T. Ensfelder,‡a   Matthias Q. Kurz, ORCID logo ‡a   Katharina Iwan, ORCID logo ‡a   Simon Geiger,a   Sarah Matheisl,b   Markus Müller, ORCID logo a   Roland Beckmannb  and  Thomas Carell ORCID logo *a  

* Corresponding authors

a Center for Integrated Protein Science, Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377 Munich, Germany
E-mail: Thomas.carell@lmu.de
Web: http://www.carellgroup.de

b Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25, 81377 Munich, Germany

Abstract

RNA contains methylated A-base derivatives. A methylation to m6A and then demethylation regulate homeostasis in mRNA. It is assumed that m6A is mainly demethylated by the α-ketoglutarate dependent oxidase ALKBH5. Here we show that ALKBH5 also demethylates the dimethylated adenosine m62A, which is a non-canonical base present in ribosomal RNA.

Graphical abstract: ALKBH5-induced demethylation of mono- and dimethylated adenosine

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Article information

DOI
https://doi.org/10.1039/C8CC03980A
Article type
Communication
Submitted
18 May 2018
Accepted
04 Jul 2018
First published
05 Jul 2018

Chem. Commun., 2018,54, 8591-8593

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ALKBH5-induced demethylation of mono- and dimethylated adenosine

T. T. Ensfelder, M. Q. Kurz, K. Iwan, S. Geiger, S. Matheisl, M. Müller, R. Beckmann and T. Carell, Chem. Commun., 2018, 54, 8591 DOI: 10.1039/C8CC03980A

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