Issue 51, 2018
From the journal:

Chemical Communications

Water proton NMR detection of amide hydrolysis and diglycine dimerization†

Katharine T. Briggs,a   Marc B. Taraban ORCID logo a  and  Y. Bruce Yu*a  

* Corresponding authors

a Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD, USA
E-mail: byu@rx.umaryland.edu

Abstract

The transverse relaxation rate of water protons R2(1H2O) is found to be sensitive to amide hydrolysis and diglycine dimerization. The results demonstrate the feasibility of using R2(1H2O) as a diagnostic tool to detect chemical changes in aqueous solutions. Potential applications include drug product formulation and inspection.

Graphical abstract: Water proton NMR detection of amide hydrolysis and diglycine dimerization

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Article information

DOI
https://doi.org/10.1039/C8CC03935F
Article type
Communication
Submitted
16 May 2018
Accepted
21 May 2018
First published
21 May 2018

Chem. Commun., 2018,54, 7003-7006

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Water proton NMR detection of amide hydrolysis and diglycine dimerization

K. T. Briggs, M. B. Taraban and Y. B. Yu, Chem. Commun., 2018, 54, 7003 DOI: 10.1039/C8CC03935F

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