Issue 58, 2018
From the journal:

Chemical Communications

Towards a sustainable synthesis of amides: chemoselective palladium-catalysed aminocarbonylation of aryl iodides in deep eutectic solvents†

Francesco Messa, ORCID logo a   Serena Perrone,a   Martina Capua,a   Francesco Tolomeo,a   Luigino Troisi,a   Vito Capriati ORCID logo *b  and  Antonio Salomone ORCID logo *a  

* Corresponding authors

a Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Prov.le Lecce-Monteroni, Lecce, Italy
E-mail: antonio.salomone@unisalento.it

b Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, Consorzio C.I.N.M.P.I.S., Via E. Orabona 4, Bari, Italy
E-mail: vito.capriati@uniba.it

Abstract

A palladium-catalysed aminocarbonylation of (hetero)aryl iodides has, for the first time, been accomplished in deep eutectic solvents as environmentally benign and recyclable media, under mild conditions. The reactions proceeded with a good substrate scope, and a variety of amides have been synthesized in yields up to 98%.

Graphical abstract: Towards a sustainable synthesis of amides: chemoselective palladium-catalysed aminocarbonylation of aryl iodides in deep eutectic solvents

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Article information

DOI
https://doi.org/10.1039/C8CC03858A
Article type
Communication
Submitted
14 May 2018
Accepted
25 Jun 2018
First published
25 Jun 2018

Chem. Commun., 2018,54, 8100-8103

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Towards a sustainable synthesis of amides: chemoselective palladium-catalysed aminocarbonylation of aryl iodides in deep eutectic solvents

F. Messa, S. Perrone, M. Capua, F. Tolomeo, L. Troisi, V. Capriati and A. Salomone, Chem. Commun., 2018, 54, 8100 DOI: 10.1039/C8CC03858A

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