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Issue 53, 2018
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Electrochemical sensing of attomolar miRNA combining cascade strand displacement polymerization and reductant-mediated amplification

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Abstract

Herein, we have developed a distinctive electrochemical sensing platform for miRNA assay. Target miRNA initiates two cycles of polymerization, nicking, and displacement reactions, which lead to the variation of the distance between redox molecules and the electrode surface. In addition, a reductant is employed for further electrochemical amplification.

Graphical abstract: Electrochemical sensing of attomolar miRNA combining cascade strand displacement polymerization and reductant-mediated amplification

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Publication details

The article was received on 08 May 2018, accepted on 12 Jun 2018 and first published on 12 Jun 2018


Article type: Communication
DOI: 10.1039/C8CC03698E
Citation: Chem. Commun., 2018,54, 7366-7369
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    Electrochemical sensing of attomolar miRNA combining cascade strand displacement polymerization and reductant-mediated amplification

    P. Miao, Y. Jiang, T. Zhang, Y. Huang and Y. Tang, Chem. Commun., 2018, 54, 7366
    DOI: 10.1039/C8CC03698E

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