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Issue 55, 2018
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Discovery and synthesis of the first selective BAG domain modulator of BAG3 as an attractive candidate for the development of a new class of chemotherapeutics

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Abstract

BAG3 protein has emerged as a key regulator of important cellular processes and its expression is increased in some tumor types; however, despite its potential value for future chemotherapeutics, no selective BAG3 modulators have been yet reported. Here we report the 2,4-thiazolidinedione derivative 28 as the first BAG3 protein modulator.

Graphical abstract: Discovery and synthesis of the first selective BAG domain modulator of BAG3 as an attractive candidate for the development of a new class of chemotherapeutics

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Publication details

The article was received on 26 Apr 2018, accepted on 07 Jun 2018 and first published on 11 Jun 2018


Article type: Communication
DOI: 10.1039/C8CC03399D
Citation: Chem. Commun., 2018,54, 7613-7616
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    Discovery and synthesis of the first selective BAG domain modulator of BAG3 as an attractive candidate for the development of a new class of chemotherapeutics

    S. Terracciano, G. Lauro, A. Russo, M. C. Vaccaro, A. Vassallo, M. De Marco, B. Ranieri, A. Rosati, M. C. Turco, R. Riccio, G. Bifulco and I. Bruno, Chem. Commun., 2018, 54, 7613
    DOI: 10.1039/C8CC03399D

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