Jump to main content
Jump to site search


Charge Designable and Tunable GFP as a Target pH-Responsive Carrier for Intracellular Functional Protein Delivery and Tracing

Abstract

A charge designable and tunable green fluorescent protein (GFP)-based protein delivery strategy was proposed. The acquired His29GFP selectively permeates cell membrane at target pH 6.5 and escapes from endosome efficiently. The delivered RNase A caused substantial mRNA degradation in Hela cells, and proliferation inhibition in different cell lines and 3D tumor model at pH 6.5.

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Apr 2018, accepted on 11 Jun 2018 and first published on 12 Jun 2018


Article type: Communication
DOI: 10.1039/C8CC03285H
Citation: Chem. Commun., 2018, Accepted Manuscript
  •   Request permissions

    Charge Designable and Tunable GFP as a Target pH-Responsive Carrier for Intracellular Functional Protein Delivery and Tracing

    S. Hu, X. Chen, C. Lei, R. Tang, W. Kang, H. Deng, Y. Huang, Z. Nie and S. Yao, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC03285H

Search articles by author

Spotlight

Advertisements