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Issue 56, 2018
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Charge designable and tunable GFP as a target pH-responsive carrier for intracellular functional protein delivery and tracing

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Abstract

A charge designable and tunable green fluorescent protein (GFP)-based protein delivery strategy was proposed. The acquired His29GFP selectively permeates the cell membrane at a target pH of 6.5 and escapes from the endosome efficiently. The delivered RNase A caused substantial mRNA degradation in HeLa cells, and proliferation inhibition in different cell lines and a 3D tumor model at pH 6.5.

Graphical abstract: Charge designable and tunable GFP as a target pH-responsive carrier for intracellular functional protein delivery and tracing

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Publication details

The article was received on 23 Apr 2018, accepted on 11 Jun 2018 and first published on 12 Jun 2018


Article type: Communication
DOI: 10.1039/C8CC03285H
Citation: Chem. Commun., 2018,54, 7806-7809
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    Charge designable and tunable GFP as a target pH-responsive carrier for intracellular functional protein delivery and tracing

    S. Hu, X. Chen, C. Lei, R. Tang, W. Kang, H. Deng, Y. Huang, Z. Nie and S. Yao, Chem. Commun., 2018, 54, 7806
    DOI: 10.1039/C8CC03285H

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