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Issue 47, 2018
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Ligand-promoted ruthenium-catalyzed meta C–H chlorination of arenes using N-chloro-2,10-camphorsultam

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Abstract

A practical meta C–H chlorination protocol is established via a Ru(0)-catalyzed ortho-metalation strategy. The use of N-chloro-2,10-camphorsultam as a new chlorinating agent is crucial for the success of the current reaction and an N-heterocyclic carbene (NHC) ligand could significantly enhance the reactivity of the catalytic transformation. The mechanistic studies reveal that an unusual ortho C–H ruthenation relay process with ortho chlorination of the C–Ru bond is probably involved.

Graphical abstract: Ligand-promoted ruthenium-catalyzed meta C–H chlorination of arenes using N-chloro-2,10-camphorsultam

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Publication details

The article was received on 20 Apr 2018, accepted on 15 May 2018 and first published on 15 May 2018


Article type: Communication
DOI: 10.1039/C8CC03195A
Citation: Chem. Commun., 2018,54, 6008-6011
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    Ligand-promoted ruthenium-catalyzed meta C–H chlorination of arenes using N-chloro-2,10-camphorsultam

    Z. Fan, H. Lu, Z. Cheng and A. Zhang, Chem. Commun., 2018, 54, 6008
    DOI: 10.1039/C8CC03195A

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