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Issue 54, 2018
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Weakly-coordinating N-oxide and carbonyl groups for metal-catalyzed C–H activation: the case of A-ring functionalization

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Abstract

Compounds featuring weakly-coordinating N-oxides or carbonyl groups, as for instance, quinoline N-oxide and quinonoid systems represent important structural scaffolds with potential biological activities. Due to their biological importance, significant efforts have been devoted to devise robust methods for their step-economical preparation. Among these approaches, the C–H activation strategy has emerged as a powerful, versatile and efficient tool in molecular sciences. This feature article summarizes recent key advances in transition-metal-catalyzed C–H functionalization for A-ring functionalization of heterocyclic and quinoidal compounds by challenging weakly-coordinating entities, published prior to May 2018.

Graphical abstract: Weakly-coordinating N-oxide and carbonyl groups for metal-catalyzed C–H activation: the case of A-ring functionalization

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Publication details

The article was received on 18 Apr 2018, accepted on 14 May 2018 and first published on 14 May 2018


Article type: Feature Article
DOI: 10.1039/C8CC03147A
Citation: Chem. Commun., 2018,54, 7398-7411
  • Open access: Creative Commons BY-NC license
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    Weakly-coordinating N-oxide and carbonyl groups for metal-catalyzed C–H activation: the case of A-ring functionalization

    E. N. da Silva Júnior, G. A. M. Jardim, R. S. Gomes, Y. Liang and L. Ackermann, Chem. Commun., 2018, 54, 7398
    DOI: 10.1039/C8CC03147A

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