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Issue 54, 2018
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Zinc-catalyzed reaction of isoxazoles with thioynol ethers involving an unprecedented 1,2-sulfur migration

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Abstract

A novel zinc-catalyzed reaction of isoxazoles with thioynol ethers involving an unprecedented 1,2-sulfur migration has been developed, which represents the first example of a non-noble metal-catalyzed reaction between isoxazoles and alkynes. This method allows the facile and atom-economical synthesis of a range of valuable β-keto enamides. Moreover, the computational study provides further evidence for the feasibility of the proposed reaction mechanism.

Graphical abstract: Zinc-catalyzed reaction of isoxazoles with thioynol ethers involving an unprecedented 1,2-sulfur migration

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Publication details

The article was received on 18 Apr 2018, accepted on 15 May 2018 and first published on 16 May 2018


Article type: Communication
DOI: 10.1039/C8CC03140A
Citation: Chem. Commun., 2018,54, 7435-7438
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    Zinc-catalyzed reaction of isoxazoles with thioynol ethers involving an unprecedented 1,2-sulfur migration

    X. Zhu, Q. Sun, Z. Zhang, B. Zhou, P. Xie, W. Shen, X. Lu, J. Zhou and L. Ye, Chem. Commun., 2018, 54, 7435
    DOI: 10.1039/C8CC03140A

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