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Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots for in vivo HER-2 receptor-targeted imaging

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Abstract

We developed highly bright and stable far-red emissive AIEdots by using a new kind of click-functional PEG grafted amphiphilic polymer to coat hydrophobic AIE-active polymers (PDFDP). Furthermore, an anti-HER2 recombinant fully human antibody was produced and conjugated on the AIEdots via metal-free click chemistry to fabricate in vivo tumor-targeting nanoprobes.

Graphical abstract: Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots for in vivo HER-2 receptor-targeted imaging

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Publication details

The article was received on 16 Apr 2018, accepted on 01 Jun 2018 and first published on 04 Jun 2018


Article type: Communication
DOI: 10.1039/C8CC03037E
Citation: Chem. Commun., 2018, Advance Article
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    Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots for in vivo HER-2 receptor-targeted imaging

    Y. Wu, Z. Chen, P. Zhang, L. Zhou, T. Jiang, H. Chen, P. Gong, D. S. Dimitrov, L. Cai and Q. Zhao, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC03037E

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