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A supramolecular photosensitizer system based on the host-guest complexation between water-soluble pillar[6]arene and methylene blue for durable photodynamic therapy

Abstract

A supramolecular photosensitizer system WP6-MB was synthesized based on water-soluble pillar[6]arene and photosensitizer methylene blue (MB) via host-guest interaction. MB can complex with WP6 directly with high complex constant without further modification. In particular, WP6-MB can reduce the dark toxicity of MB remarkably. Furthermore, it can efficiently overcome photobleaching and extend the time for singlet oxygen production of MB upon light irradiation, which is significant for durable photodynamic therapy.

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Publication details

The article was received on 05 Apr 2018, accepted on 14 May 2018 and first published on 15 May 2018


Article type: Communication
DOI: 10.1039/C8CC02739K
Citation: Chem. Commun., 2018, Accepted Manuscript
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    A supramolecular photosensitizer system based on the host-guest complexation between water-soluble pillar[6]arene and methylene blue for durable photodynamic therapy

    K. Yang, J. Wen, S. Chao, J. Liu, K. Yang, Y. Pei and Z. Pei, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC02739K

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