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Super-resolution force spectroscopy reveals ribosomal motion at sub-nucleotide steps

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Abstract

Probing biomolecular motion beyond a single nucleotide is technically challenging but fundamentally significant. We have developed super-resolution force spectroscopy (SURFS) with 0.5 pN force resolution and revealed that the ribosome moves by half a nucleotide upon the formation of the pre-translocation complex, which is beyond the resolution of other techniques.

Graphical abstract: Super-resolution force spectroscopy reveals ribosomal motion at sub-nucleotide steps

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Publication details

The article was received on 03 Apr 2018, accepted on 11 May 2018 and first published on 14 May 2018


Article type: Communication
DOI: 10.1039/C8CC02658K
Citation: Chem. Commun., 2018, Advance Article
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    Super-resolution force spectroscopy reveals ribosomal motion at sub-nucleotide steps

    H. Jia, Y. Wang and S. Xu, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC02658K

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