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Issue 45, 2018
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Pd-Catalyzed reductive heck reaction of olefins with aryl bromides for Csp2–Csp3 bond formation

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Abstract

We developed a Pd-catalyzed intermolecular reductive Heck reaction to construct Csp2–Csp3 bonds between aryl bromides and olefins. Various styrene derivatives, acyclic and cyclic alkenes, were well tolerated to couple with varied aryl bromides in linear selectivity. Kinetic and deuterium labeling experiments suggested that i-PrOH provides a hydride through β-H elimination.

Graphical abstract: Pd-Catalyzed reductive heck reaction of olefins with aryl bromides for Csp2–Csp3 bond formation

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Publication details

The article was received on 30 Mar 2018, accepted on 11 May 2018 and first published on 12 May 2018


Article type: Communication
DOI: 10.1039/C8CC02571A
Citation: Chem. Commun., 2018,54, 5752-5755
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    Pd-Catalyzed reductive heck reaction of olefins with aryl bromides for Csp2–Csp3 bond formation

    L. Jin, J. Qian, N. Sun, B. Hu, Z. Shen and X. Hu, Chem. Commun., 2018, 54, 5752
    DOI: 10.1039/C8CC02571A

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