Issue 45, 2018
From the journal:

Chemical Communications

Substrate mediated redox partner selectivity of cytochrome P450†

Katherine A. Gentry,*a   Meng Zhang,a   Sang-Choul Im,b   Lucy Waskellb  and  Ayyalusamy Ramamoorthy ORCID logo a  

* Corresponding authors

a Biophysics and Department of Chemistry, University of Michigan, Ann Arbor, USA
E-mail: ramamoor@umich.edu

b Department of Anaesthesiology, University of Michigan and VA Medical Center, Ann Arbor, USA

Abstract

Investigating the interplay between cytochrome-P450 and its redox partners (CPR and cytochrome-b5) is vital for understanding the metabolism of most hydrophobic drugs. Dynamic structural interactions with the ternary complex, with and without substrates, captured by NMR reveal a gating mechanism for redox partners to promote P450 function.

Graphical abstract: Substrate mediated redox partner selectivity of cytochrome P450

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Article information

DOI
https://doi.org/10.1039/C8CC02525H
Article type
Communication
Submitted
28 Mar 2018
Accepted
06 May 2018
First published
10 May 2018

Chem. Commun., 2018,54, 5780-5783

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Substrate mediated redox partner selectivity of cytochrome P450

K. A. Gentry, M. Zhang, S. Im, L. Waskell and A. Ramamoorthy, Chem. Commun., 2018, 54, 5780 DOI: 10.1039/C8CC02525H

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