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Issue 45, 2018
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Substrate mediated redox partner selectivity of cytochrome P450

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Abstract

Investigating the interplay between cytochrome-P450 and its redox partners (CPR and cytochrome-b5) is vital for understanding the metabolism of most hydrophobic drugs. Dynamic structural interactions with the ternary complex, with and without substrates, captured by NMR reveal a gating mechanism for redox partners to promote P450 function.

Graphical abstract: Substrate mediated redox partner selectivity of cytochrome P450

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Publication details

The article was received on 28 Mar 2018, accepted on 06 May 2018 and first published on 10 May 2018


Article type: Communication
DOI: 10.1039/C8CC02525H
Citation: Chem. Commun., 2018,54, 5780-5783
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    Substrate mediated redox partner selectivity of cytochrome P450

    K. A. Gentry, M. Zhang, S. Im, L. Waskell and A. Ramamoorthy, Chem. Commun., 2018, 54, 5780
    DOI: 10.1039/C8CC02525H

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