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Homologation Chemistry with α-Substituted Organometallic Reagents: Chemocontrol, New Concepts and (Solved) Challenges

Abstract

The transfer of a reactive nucleophilic CH2X unit into a preformed bond enables the introduction of the fragment featuring the exact and desired degree of functionalization through a single synthetic operation. The instability of metallated α-organometallic species often poses serious questions on the practicability of using this conceptually intuitive and simple approach for forming C-C or C-heteroatom bonds. The deep understanding of processes regulating the formation of these nucleophiles is a precious source of inspiration not only for successfully applying theoretically feasible transformations (i.e. determining how to employ a given reagent), but also for designing new reactions which ultimately lead to introduce molecular complexity via short experimental sequences.

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Publication details

The article was received on 28 Mar 2018, accepted on 17 May 2018 and first published on 17 May 2018


Article type: Feature Article
DOI: 10.1039/C8CC02499E
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Homologation Chemistry with α-Substituted Organometallic Reagents: Chemocontrol, New Concepts and (Solved) Challenges

    L. Castoldi, S. Monticelli, R. Senatore, L. Ielo and V. Pace, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC02499E

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