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Issue 50, 2018
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Synthesis of unsymmetrical Si-rhodamine fluorophores and application to a far-red to near-infrared fluorescence probe for hypoxia

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Abstract

Si-Rhodamines are bright fluorophores with red to near-infrared (NIR) emission, and are widely used for fluorescence imaging of biological phenomena. Here, in order to extend the scope of Si-rhodamine fluorophores, we established a versatile synthesis of unsymmetrical Si-rhodamines. To illustrate its value, we used one of these new fluorophores to synthesize a far-red to NIR fluorescence probe for hypoxia, and showed that it can visualize hepatic ischemia in mice in vivo.

Graphical abstract: Synthesis of unsymmetrical Si-rhodamine fluorophores and application to a far-red to near-infrared fluorescence probe for hypoxia

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Publication details

The article was received on 02 Apr 2018, accepted on 25 May 2018 and first published on 28 May 2018


Article type: Communication
DOI: 10.1039/C8CC02451K
Citation: Chem. Commun., 2018,54, 6939-6942
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    Synthesis of unsymmetrical Si-rhodamine fluorophores and application to a far-red to near-infrared fluorescence probe for hypoxia

    K. Hanaoka, Y. Kagami, W. Piao, T. Myochin, K. Numasawa, Y. Kuriki, T. Ikeno, T. Ueno, T. Komatsu, T. Terai, T. Nagano and Y. Urano, Chem. Commun., 2018, 54, 6939
    DOI: 10.1039/C8CC02451K

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