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Issue 40, 2018
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An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria

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Abstract

We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Pseudomonas aeruginosa.

Graphical abstract: An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria

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Publication details

The article was received on 26 Mar 2018, accepted on 23 Apr 2018 and first published on 23 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC02412J
Citation: Chem. Commun., 2018,54, 5130-5133
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    An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria

    I. Di Bonaventura, S. Baeriswyl, A. Capecchi, B. Gan, X. Jin, T. N. Siriwardena, R. He, T. Köhler, A. Pompilio, G. Di Bonaventura, C. van Delden, S. Javor and J. Reymond, Chem. Commun., 2018, 54, 5130
    DOI: 10.1039/C8CC02412J

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