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Issue 50, 2018
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Expanding the limit of Pd-catalyzed decarboxylative benzylations

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Abstract

The Pd-catalyzed decarboxylative cross-coupling of electron-deficient aryl acetates with aryl bromides is reported. The method widens the scope of benzylic partners that can undergo efficient reactivity from highly activated nitrophenylacetates established previously, to a diverse series of substrates bearing modestly stabilizing groups, allowing direct access to functionalized diarylmethanes. Mechanistic studies support the role of dienolates as key intermediates in the coupling process.

Graphical abstract: Expanding the limit of Pd-catalyzed decarboxylative benzylations

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Publication details

The article was received on 26 Mar 2018, accepted on 17 Apr 2018 and first published on 17 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC02380H
Citation: Chem. Commun., 2018,54, 6835-6838
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    Expanding the limit of Pd-catalyzed decarboxylative benzylations

    D. Kong, P. J. Moon, W. Qian and R. J. Lundgren, Chem. Commun., 2018, 54, 6835
    DOI: 10.1039/C8CC02380H

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