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A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

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Abstract

Heat stroke is a lethal condition which can cause dysfunction in the central nervous system, multi-organ damage and even death. However, there is still limited knowledge of the detailed mechanism about the roles of lysosomes in heat stroke due to lack of effective tools. Herein, we introduce our previously developed hemicyanine with a large D–π–A structure as the key fluorophore to develop a new fluorescent probe (CPY) for ratiometric mapping of lysosomal pH changes in live cells under a heat shock stimulus.

Graphical abstract: A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

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Publication details

The article was received on 23 Mar 2018, accepted on 09 Apr 2018 and first published on 11 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC02330A
Citation: Chem. Commun., 2018, Advance Article
  • Open access: Creative Commons BY license
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    A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

    L. Wu, Y. Wang, T. D. James, N. Jia and C. Huang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC02330A

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