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Issue 50, 2018
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Total syntheses of spirocyclic PKS-NRPS-based fungal metabolites

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Abstract

Since the first isolation of pseurotin A in 1976, over twenty five spirocyclic PKS-NRPS-based (polyketide synthase-nonribosomal peptide synthetase-based) fungal natural products have been discovered to date. The common 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione core of this family of natural products has served as a platform for the development of novel chemistry and resulted in the development of numerous new reactivities and synthetic strategies. Herein, we delineate all reported syntheses of spirocyclic PKS-NRPS-based fungal metabolites including our own recent contributions on this subject. We showcase how a biosynthetic consideration could lead to concise synthetic routes to this family of natural products.

Graphical abstract: Total syntheses of spirocyclic PKS-NRPS-based fungal metabolites

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Publication details

The article was received on 23 Mar 2018, accepted on 30 May 2018 and first published on 30 May 2018


Article type: Feature Article
DOI: 10.1039/C8CC02315H
Citation: Chem. Commun., 2018,54, 6750-6758
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    Total syntheses of spirocyclic PKS-NRPS-based fungal metabolites

    D. Jo and S. Han, Chem. Commun., 2018, 54, 6750
    DOI: 10.1039/C8CC02315H

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