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Development of DNA aptamers targeting low-molecular-weight amyloid-β peptide aggregates in vitro

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Abstract

We have developed a novel functional nucleic acid aptamer to amyloid-β peptide 1–40 (Aβ1–40) and investigated its potential to detect Aβ peptide fragments in neuropathologically confirmed Alzheimer brain hippocampus tissues samples. Our results demonstrate that the aptamer candidate RNV95 could detect tetrameric/pentameric low-molecular-weight Aβ aggregates in autopsy hippocampal tissue from two neuropathologically confirmed Alzheimer disease cases. Although these are preliminary observations, detailed investigations are under way. This is the first demonstration of aptamer-Aβ binding in Alzheimer brain tissues.

Graphical abstract: Development of DNA aptamers targeting low-molecular-weight amyloid-β peptide aggregates in vitro

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Publication details

The article was received on 21 Mar 2018, accepted on 10 Apr 2018 and first published on 11 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC02256A
Citation: Chem. Commun., 2018, Advance Article
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    Development of DNA aptamers targeting low-molecular-weight amyloid-β peptide aggregates in vitro

    M. Chakravarthy, H. AlShamaileh, H. Huang, R. K. Tannenberg, S. Chen, S. Worrall, P. R. Dodd and R. N. Veedu, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC02256A

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