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N-Heterocyclic carbene-catalyzed annulation of ynals with amidines: access to 1,2,6-trisubstituted pyrimidin-4-ones

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Abstract

An N-heterocyclic carbene-catalyzed annulation of ynals and amidines has been reported to construct pyrimidin-4-ones. The protocol features a broad substrate scope and mild conditions. Furthermore, an oxidative strategy to catalytically generate ynal-derived acyl azolium intermediates is discussed in this mechanistic study.

Graphical abstract: N-Heterocyclic carbene-catalyzed annulation of ynals with amidines: access to 1,2,6-trisubstituted pyrimidin-4-ones

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Publication details

The article was received on 13 Mar 2018, accepted on 11 Apr 2018 and first published on 11 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC02023J
Citation: Chem. Commun., 2018, Advance Article
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    N-Heterocyclic carbene-catalyzed annulation of ynals with amidines: access to 1,2,6-trisubstituted pyrimidin-4-ones

    Y. Xie and J. Wang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC02023J

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