Jump to main content
Jump to site search

Issue 36, 2018
Previous Article Next Article

N-Heterocyclic carbene-catalyzed annulation of ynals with amidines: access to 1,2,6-trisubstituted pyrimidin-4-ones

Author affiliations

Abstract

An N-heterocyclic carbene-catalyzed annulation of ynals and amidines has been reported to construct pyrimidin-4-ones. The protocol features a broad substrate scope and mild conditions. Furthermore, an oxidative strategy to catalytically generate ynal-derived acyl azolium intermediates is discussed in this mechanistic study.

Graphical abstract: N-Heterocyclic carbene-catalyzed annulation of ynals with amidines: access to 1,2,6-trisubstituted pyrimidin-4-ones

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Mar 2018, accepted on 11 Apr 2018 and first published on 11 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC02023J
Citation: Chem. Commun., 2018,54, 4597-4600
  •   Request permissions

    N-Heterocyclic carbene-catalyzed annulation of ynals with amidines: access to 1,2,6-trisubstituted pyrimidin-4-ones

    Y. Xie and J. Wang, Chem. Commun., 2018, 54, 4597
    DOI: 10.1039/C8CC02023J

Search articles by author

Spotlight

Advertisements