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Efficient peptide ligation between allyl-protected Asp and Cys followed by palladium-mediated deprotection

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Abstract

An efficient method for peptide ligation between C-terminal Asp(OAllyl) and N-terminal Cys has been developed. Peptide ligation and removal of the allyl group at the Asp carboxylate side chain proceeded in one pot by adding a small amount of Pd/TPPTS complex. Based on this efficient synthetic method, PEP-19 (61 amino acids), which is highly expressed in Purkinje cells, was synthesized.

Graphical abstract: Efficient peptide ligation between allyl-protected Asp and Cys followed by palladium-mediated deprotection

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Publication details

The article was received on 12 Mar 2018, accepted on 04 Apr 2018 and first published on 04 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC01965G
Citation: Chem. Commun., 2018, Advance Article
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    Efficient peptide ligation between allyl-protected Asp and Cys followed by palladium-mediated deprotection

    N. Kamo, G. Hayashi and A. Okamoto, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC01965G

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