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Issue 47, 2018
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Palladium/H+-cocatalyzed kinetic resolution of tertiary propargylic alcohols

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Abstract

A new approach to not-readily-available optically active tertiary propargylic alcohols through palladium/H+-cocatalyzed carboxylation of racemic tertiary propargylic alcohols with CO and MeOH has been described. Both enantiomers can be obtained with no less than 90% ee utilizing (R) or (S)-DTBM-Segphos. Various transformations of the optically active alcohols have been demonstrated.

Graphical abstract: Palladium/H+-cocatalyzed kinetic resolution of tertiary propargylic alcohols

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Publication details

The article was received on 11 Mar 2018, accepted on 09 May 2018 and first published on 11 May 2018


Article type: Communication
DOI: 10.1039/C8CC01949E
Citation: Chem. Commun., 2018,54, 6064-6067
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    Palladium/H+-cocatalyzed kinetic resolution of tertiary propargylic alcohols

    W. Zhang and S. Ma, Chem. Commun., 2018, 54, 6064
    DOI: 10.1039/C8CC01949E

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