Jump to main content
Jump to site search


Palladium/H+-Cocatalyzed Kinetic Resolution of tertiary Propargylic Alcohols

Abstract

A new approach to not-readily-available optically active tertiary propargylic alcohols through palladium/H+-cocatalyzed carboxylation of racemic tertiary propargylic alcohols with CO and MeOH has been described. Both enantiomers can be obtained with > 90% ee applying (R) or (S)-DTBM-Segphos. Various transformations of the optically active alcohols have been demonstrated.

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Mar 2018, accepted on 09 May 2018 and first published on 11 May 2018


Article type: Communication
DOI: 10.1039/C8CC01949E
Citation: Chem. Commun., 2018, Accepted Manuscript
  •   Request permissions

    Palladium/H+-Cocatalyzed Kinetic Resolution of tertiary Propargylic Alcohols

    W. Zhang and S. Ma, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC01949E

Search articles by author

Spotlight

Advertisements