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An MTH1-targeted nanosystem for enhanced PDT via improving cellular sensitivity to reactive oxygen species

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Abstract

Herein, we developed a strategy to attack the cancer cell defense system against reactive oxygen species to improve photodynamic therapy efficacy with a Ce6@MSN@MTH1 siRNA nanosystem, which was demonstrated to improve cellular sensitivity to reactive oxygen species through suppressing MTH1 protein in cancer cells.

Graphical abstract: An MTH1-targeted nanosystem for enhanced PDT via improving cellular sensitivity to reactive oxygen species

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Publication details

The article was received on 07 Mar 2018, accepted on 03 Apr 2018 and first published on 04 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC01841C
Citation: Chem. Commun., 2018, Advance Article
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    An MTH1-targeted nanosystem for enhanced PDT via improving cellular sensitivity to reactive oxygen species

    H. Fan, L. Zhang, X. Hu, Z. Zhao, H. Bai, X. Fu, G. Yan, L. Liang, X. Zhang and W. Tan, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC01841C

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