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Issue 34, 2018
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Manganese catalyzed reductive amination of aldehydes using hydrogen as a reductant

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Abstract

A one-pot two-step procedure was developed for the alkylation of amines via reductive amination of aldehydes using molecular dihydrogen as a reductant in the presence of a manganese pyridinyl-phosphine complex as a pre-catalyst. After the initial condensation step, the reduction of imines formed in situ is performed under mild conditions (50–100 °C) with 2 mol% of catalyst and 5 mol% of tBuOK under 50 bar of hydrogen. Excellent yields (>90%) were obtained for a large combination of aldehydes and amines (40 examples), including aliphatic aldehydes and amino-alcohols.

Graphical abstract: Manganese catalyzed reductive amination of aldehydes using hydrogen as a reductant

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Publication details

The article was received on 05 Mar 2018, accepted on 25 Mar 2018 and first published on 27 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC01787E
Citation: Chem. Commun., 2018,54, 4302-4305
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    Manganese catalyzed reductive amination of aldehydes using hydrogen as a reductant

    D. Wei, A. Bruneau-Voisine, D. A. Valyaev, N. Lugan and J. Sortais, Chem. Commun., 2018, 54, 4302
    DOI: 10.1039/C8CC01787E

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