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2-(1-Methylhydrazinyl)pyridine-Directed C−H Functionalization/Spirocyclization Cascade: Facile Access to Spiro-succinimide Derivatives

Abstract

A cobalt-catalyzed oxidative coupling of benzoic hydrazides with maleimides by utilizing 2-(1-methylhydrazinyl)pyridine as a bidentate directing group has been developed. This C−H functionalization/spirocyclization cascade protocol shows high efficiency and remarkable functional group tolerance, and the ubiquitous spirosuccinimides were obtained in good to excel-lent yields with high regioselectivity. This strategy also provides a novel and efficient access to diverse symmetric and un-symmetrical bisspirosuccinimides.

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Publication details

The article was received on 05 Mar 2018, accepted on 11 Apr 2018 and first published on 12 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC01774C
Citation: Chem. Commun., 2018, Accepted Manuscript
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    2-(1-Methylhydrazinyl)pyridine-Directed C−H Functionalization/Spirocyclization Cascade: Facile Access to Spiro-succinimide Derivatives

    H. Zhao, X. Shao, T. Wang, S. Zhai, S. Qiu, C. Tao, H. Wang and H. Zhai, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC01774C

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