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Issue 28, 2018
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Intracellular self-assembly of Ru(bpy)32+ nanoparticles enables persistent phosphorescence imaging of tumors

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Abstract

Nanoprobes are advantageous over small molecular probes in sensitivity but most luminescence molecules used to construct nanoprobes often suffer from an aggregation-caused quenching effect. Herein, we rationally designed a small molecular probe Cys(StBu)-Lys(Ru(bpy)32+)-CBT (1) which “smartly” self-assembled into nanoparticles 1-NPs inside cells with non-quenched, persistent phosphorescence. Employing this property, we successfully applied 1 for long-term sensing of biothiol activity in living HepG2 cells and tumors. We envision that, by modifying the amino group with an enzyme substrate, our probe 1 could be further developed for sensing intracellular enzyme activity with non-quenched, persistent phosphorescence.

Graphical abstract: Intracellular self-assembly of Ru(bpy)32+ nanoparticles enables persistent phosphorescence imaging of tumors

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Publication details

The article was received on 04 Mar 2018, accepted on 12 Mar 2018 and first published on 12 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC01759J
Citation: Chem. Commun., 2018,54, 3460-3463
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    Intracellular self-assembly of Ru(bpy)32+ nanoparticles enables persistent phosphorescence imaging of tumors

    J. Li, Z. Hai, H. Xiao, X. Yi and G. Liang, Chem. Commun., 2018, 54, 3460
    DOI: 10.1039/C8CC01759J

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