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Issue 32, 2018
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An organocatalytic enantioselective direct α-heteroarylation of aldehydes with isoquinoline N-oxides

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Abstract

A new protocol for the enantioselective direct α-heteroarylation of aldehydes with isoquinoline N-oxides, via chiral enamine catalysis, has been successfully developed. High enantiomeric excesses and moderate to good yields were achieved for a variety of α-heteroarylated aldehydes.

Graphical abstract: An organocatalytic enantioselective direct α-heteroarylation of aldehydes with isoquinoline N-oxides

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Publication details

The article was received on 02 Mar 2018, accepted on 12 Mar 2018 and first published on 13 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC01735B
Citation: Chem. Commun., 2018,54, 3977-3980
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    An organocatalytic enantioselective direct α-heteroarylation of aldehydes with isoquinoline N-oxides

    G. Bertuzzi, D. Pecorari, L. Bernardi and M. Fochi, Chem. Commun., 2018, 54, 3977
    DOI: 10.1039/C8CC01735B

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