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Issue 55, 2018
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A novel three-fluorophore system as a ratiometric sensor for multiple protease detection

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Abstract

A synthetic three-fluorophore system with two enzymatically cleavable linkers has been developed for the simultaneous detection of two proteases in a mixture. The probe was designed to afford single excitation/triple emission ratiometric detection through a fluorescence change during the cleavage of a peptide linker. The developed assays were verified for trypsin and chymotrypsin as the model enzymes.

Graphical abstract: A novel three-fluorophore system as a ratiometric sensor for multiple protease detection

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Publication details

The article was received on 02 Mar 2018, accepted on 14 May 2018 and first published on 14 May 2018


Article type: Communication
DOI: 10.1039/C8CC01731J
Citation: Chem. Commun., 2018,54, 7589-7592
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    A novel three-fluorophore system as a ratiometric sensor for multiple protease detection

    Y. Okorochenkova, M. Porubský, S. Benická and J. Hlaváč, Chem. Commun., 2018, 54, 7589
    DOI: 10.1039/C8CC01731J

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