In this work, we report selection of covalent linker on anomeric position of N-azidoacetylmannosamine (ManNAz) for caging its metabolic process. We synthesized DT-diaphorase responsive metabolic precursor HQ-NN-AAM using the optimized linker. The caged metabolite showed responsiveness to DT-diaphorase in vitro, resulting in metabolic incorporation of azido sugar on cell surface in multiple cell lines.
The article was received on 01 Mar 2018, accepted on 03 Apr 2018 and first published on 03 Apr 2018
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