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Caged metabolic precursor for DT-diaphorase responsive cell labeling

Abstract

In this work, we report selection of covalent linker on anomeric position of N-azidoacetylmannosamine (ManNAz) for caging its metabolic process. We synthesized DT-diaphorase responsive metabolic precursor HQ-NN-AAM using the optimized linker. The caged metabolite showed responsiveness to DT-diaphorase in vitro, resulting in metabolic incorporation of azido sugar on cell surface in multiple cell lines.

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Publication details

The article was received on 01 Mar 2018, accepted on 03 Apr 2018 and first published on 03 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC01715H
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Caged metabolic precursor for DT-diaphorase responsive cell labeling

    R. Wang, K. Cai, H. Wang, C. Yin and J. Cheng, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC01715H

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