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Issue 38, 2018
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A caged metabolic precursor for DT-diaphorase-responsive cell labeling

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Abstract

In this study, we report incorporation of a covalent linker at the anomeric position of N-azidoacetylmannosamine (ManNAz) for caging its metabolic process. We synthesized a DT-diaphorase-responsive metabolic precursor, HQ-NN-AAM, using an optimized linker. The caged metabolite showed responsiveness to DT-diaphorase in vitro, resulting in metabolic incorporation of an azido sugar into the cell surface in multiple cell lines.

Graphical abstract: A caged metabolic precursor for DT-diaphorase-responsive cell labeling

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Publication details

The article was received on 01 Mar 2018, accepted on 03 Apr 2018 and first published on 03 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC01715H
Citation: Chem. Commun., 2018,54, 4878-4881
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    A caged metabolic precursor for DT-diaphorase-responsive cell labeling

    R. Wang, K. Cai, H. Wang, C. Yin and J. Cheng, Chem. Commun., 2018, 54, 4878
    DOI: 10.1039/C8CC01715H

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