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Issue 33, 2018
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Oxidation-induced generation of a mild electrophile for proximity-enhanced protein–protein crosslinking

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Abstract

We report a strategy to introduce a reactive electrophile into proteins through the conversion of a chemically inert group into a bioreactive group in response to an inducer molecule. This strategy was demonstrated by oxidation-induced and proximity-enhanced protein–protein crosslinking in the presence of a large excess of free nucleophile.

Graphical abstract: Oxidation-induced generation of a mild electrophile for proximity-enhanced protein–protein crosslinking

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Publication details

The article was received on 27 Feb 2018, accepted on 24 Mar 2018 and first published on 26 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC01639A
Citation: Chem. Commun., 2018,54, 4172-4175
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    Oxidation-induced generation of a mild electrophile for proximity-enhanced protein–protein crosslinking

    X. Shang, Y. Chen, N. Wang, W. Niu and J. Guo, Chem. Commun., 2018, 54, 4172
    DOI: 10.1039/C8CC01639A

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