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A pH-controlled bidirectionally pure DNA hydrogel: reversible self-assembly and fluorescence monitoring

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Abstract

A concept for a pure DNA hydrogel has been demonstrated in which triplex structures act as the core components and are assisted by single strands and artfully designed Y-shaped structures. Typically, the triplex structure which is based on protonated cytosine–guanine–cytosine (C–G·C+) is formed at pH 5.0 and disassembles at pH 7.0, whereas the thymine–adenine–thymine (T–A·T)-based triplex structure is formed at pH 7.0 and disassembles at pH 10.0. Therefore, such triplex DNA structure-based pure DNA hydrogels provide pH-controlled reversible self-assembly of DNA structures with a transition between gel and liquid states. More significantly, the introduction of both a fluorophore (FAM) and a quencher (BHQ1) to the hydrogels provides an innovative method for monitoring the self-assembly and disassembly processes through a fluorescence technology.

Graphical abstract: A pH-controlled bidirectionally pure DNA hydrogel: reversible self-assembly and fluorescence monitoring

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Publication details

The article was received on 27 Feb 2018, accepted on 10 Apr 2018 and first published on 10 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC01603H
Citation: Chem. Commun., 2018, Advance Article
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    A pH-controlled bidirectionally pure DNA hydrogel: reversible self-assembly and fluorescence monitoring

    S. Lu, S. Wang, J. Zhao, J. Sun and X. Yang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC01603H

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