Jump to main content
Jump to site search

Issue 35, 2018
Previous Article Next Article

Trisubstituted olefin synthesis via Ni-catalyzed hydroalkylation of internal alkynes with non-activated alkyl halides

Author affiliations

Abstract

The stereoselective synthesis of tri-substituted alkenes is challenging. Herein, we report a Ni-catalyzed regio- and stereo-selective hydroalkylation of internal alkynes with non-activated alkyl halides. This method does not use any sensitive organometallic reagents and shows good functional group compatibility, which enables the efficient synthesis of many tri-substituted olefins from readily available coupling partners. It also provides a straightforward method for the modification of bioactive organic molecules.

Graphical abstract: Trisubstituted olefin synthesis via Ni-catalyzed hydroalkylation of internal alkynes with non-activated alkyl halides

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Feb 2018, accepted on 27 Mar 2018 and first published on 28 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC01577E
Citation: Chem. Commun., 2018,54, 4417-4420
  •   Request permissions

    Trisubstituted olefin synthesis via Ni-catalyzed hydroalkylation of internal alkynes with non-activated alkyl halides

    X. Lu, M. Hong, H. Zhou, Y. Wang, J. Wang and X. Ge, Chem. Commun., 2018, 54, 4417
    DOI: 10.1039/C8CC01577E

Search articles by author

Spotlight

Advertisements