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Pd-catalyzed defluorination/arylation of α-trifluoromethyl ketones via consecutive β-F elimination and C–F bond activation

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Abstract

An unprecedented Pd-catalyzed activation of a CF3 group is reported herein. The key to the success of this reaction is the combination of consecutive β-F elimination and C–F bond oxidative addition of a trifluoromethyl group. It also represents the first general application of α-trifluoromethyl ketones as building blocks by CF bond activation.

Graphical abstract: Pd-catalyzed defluorination/arylation of α-trifluoromethyl ketones via consecutive β-F elimination and C–F bond activation

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Publication details

The article was received on 26 Feb 2018, accepted on 26 Mar 2018 and first published on 27 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC01568F
Citation: Chem. Commun., 2018, Advance Article
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    Pd-catalyzed defluorination/arylation of α-trifluoromethyl ketones via consecutive β-F elimination and C–F bond activation

    L. Xu, Q. Zhang, Q. Xie, B. Huang, J. Dai, J. Xu and H. Xu, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC01568F

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