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Issue 36, 2018
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Cysteine-reactive probes and their use in chemical proteomics

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Abstract

Proteomic profiling using bioorthogonal chemical probes that selectively react with certain amino acids is now a widely used method in life sciences to investigate enzymatic activities, study posttranslational modifications and discover novel covalent inhibitors. Over the past two decades, researchers have developed selective probes for several different amino acids, including lysine, serine, cysteine, threonine, tyrosine, aspartate and glutamate. Among these amino acids, cysteines are particularly interesting due to their highly diverse and complex biochemical role in our cells. In this feature article, we focus on the chemical probes and methods used to study cysteines in complex proteomes.

Graphical abstract: Cysteine-reactive probes and their use in chemical proteomics

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Publication details

The article was received on 21 Feb 2018, accepted on 05 Apr 2018 and first published on 12 Apr 2018


Article type: Feature Article
DOI: 10.1039/C8CC01485J
Citation: Chem. Commun., 2018,54, 4501-4512
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    Cysteine-reactive probes and their use in chemical proteomics

    D. G. Hoch, D. Abegg and A. Adibekian, Chem. Commun., 2018, 54, 4501
    DOI: 10.1039/C8CC01485J

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