Jump to main content
Jump to site search

Issue 27, 2018
Previous Article Next Article

Intramolecular hydrogen-bond activation for the addition of nucleophilic imines: 2-hydroxybenzophenone as a chemical auxiliary

Author affiliations

Abstract

The addition of nucleophilic imines, using 2-hydroxybenzophenone as a chemical auxiliary, is presented. An intramolecular six-membered ring via hydrogen bonding that enhances the reactivity and selectivity is the key of this strategy, which is supported by DFT calculations and experimental trials.

Graphical abstract: Intramolecular hydrogen-bond activation for the addition of nucleophilic imines: 2-hydroxybenzophenone as a chemical auxiliary

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Feb 2018, accepted on 09 Mar 2018 and first published on 09 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC01479E
Citation: Chem. Commun., 2018,54, 3399-3402
  •   Request permissions

    Intramolecular hydrogen-bond activation for the addition of nucleophilic imines: 2-hydroxybenzophenone as a chemical auxiliary

    H. Choubane, A. F. Garrido-Castro, C. Alvarado, A. Martín-Somer, A. Guerrero-Corella, M. Daaou, S. Díaz-Tendero, M. Carmen Maestro, A. Fraile and J. Alemán, Chem. Commun., 2018, 54, 3399
    DOI: 10.1039/C8CC01479E

Search articles by author

Spotlight

Advertisements