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Cp*Co(III)-catalyzed amidation of olefinic and aryl C–H bonds: highly selective synthesis of enamides and pyrimidones

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Abstract

A highly efficient and selective synthesis of enamides via C–H amidation of N-methoxy acrylamides with dioxazolones is realized under [Cp*CoIII] catalysis. The resulting enamide can further selectively cyclize to form pyrimidones, which can also act as a directing group for a second C–H amidation. All these three classes of products were selectively delivered under controlled conditions.

Graphical abstract: Cp*Co(iii)-catalyzed amidation of olefinic and aryl C–H bonds: highly selective synthesis of enamides and pyrimidones

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Publication details

The article was received on 20 Feb 2018, accepted on 29 Mar 2018 and first published on 12 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC01447G
Citation: Chem. Commun., 2018, Advance Article
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    Cp*Co(III)-catalyzed amidation of olefinic and aryl C–H bonds: highly selective synthesis of enamides and pyrimidones

    Y. Liu, F. Xie, A. Jia and X. Li, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC01447G

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