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Issue 36, 2018
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Metabolite amyloid-like fibrils interact with model membranes

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Abstract

Amyloid-like structure formation by various metabolites represents a significant extension of the amyloidogenic building block family. Similar to protein amyloids, metabolite amyloids induce apoptotic toxicity, a process that was linked to membrane association. Here, we demonstrate that metabolite amyloids interact with model membranes and study the mechanism by molecular dynamics.

Graphical abstract: Metabolite amyloid-like fibrils interact with model membranes

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Publication details

The article was received on 19 Feb 2018, accepted on 10 Apr 2018 and first published on 17 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC01423J
Citation: Chem. Commun., 2018,54, 4561-4564
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    Metabolite amyloid-like fibrils interact with model membranes

    S. Shaham-Niv, P. Rehak, D. Zaguri, S. Kolusheva, P. Král and E. Gazit, Chem. Commun., 2018, 54, 4561
    DOI: 10.1039/C8CC01423J

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