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Issue 36, 2018
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Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments

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Abstract

Alzheimer's disease (AD) is characterized by the presence of tau filaments in the brain whose structure was recently solved. The formation of AD filaments is routinely modeled in vitro by mixing tau with heparin. This study shows that heparin-induced tau filaments are markedly different from the AD filaments and are highly heterogeneous.

Graphical abstract: Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments

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Publication details

The article was received on 16 Feb 2018, accepted on 05 Apr 2018 and first published on 11 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC01355A
Citation: Chem. Commun., 2018,54, 4573-4576
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    Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments

    Y. Fichou, M. Vigers, A. K. Goring, N. A. Eschmann and S. Han, Chem. Commun., 2018, 54, 4573
    DOI: 10.1039/C8CC01355A

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