Issue 52, 2018
From the journal:

Chemical Communications

In situ semi-quantitative assessment of single-cell viability by resonance Raman spectroscopy†

Zhu Mao, ORCID logo ab   Zhuo Liu,c   Jin Yang,d   Xiaoxia Han, ORCID logo *a   Bing Zhao ORCID logo *a  and  Chun Zhaoe  

* Corresponding authors

a State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, P. R. China
E-mail: hanxiaoxia@jlu.edu.cn, zhaob@mail.jlu.edu.cn

b School of Chemistry and Life Science, Advanced Institute of Materials Science, Changchun University of Technology, Changchun, P. R. China

c China-Japan Union Hospital of Jilin University, Changchun, P. R. China

d Department of Anatomy, School of Basic Medical Sciences, Jilin University, Changchun, P. R. China

e State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, P. R. China

Abstract

Currently, studies are increasingly focusing on the cytotoxic effects of anticancer drugs. Such investigations urgently warrant the assessment of single-cell viability. Here, we developed a novel method for quantifying single-cell viability with high selectivity by resonance Raman scattering. We report on this powerful tool that will allow researchers to study cellular metabolism at the level of a single cell.

Graphical abstract: In situ semi-quantitative assessment of single-cell viability by resonance Raman spectroscopy

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Article information

DOI
https://doi.org/10.1039/C8CC01336E
Article type
Communication
Submitted
15 Feb 2018
Accepted
20 Apr 2018
First published
20 Apr 2018

Chem. Commun., 2018,54, 7135-7138

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In situ semi-quantitative assessment of single-cell viability by resonance Raman spectroscopy

Z. Mao, Z. Liu, J. Yang, X. Han, B. Zhao and C. Zhao, Chem. Commun., 2018, 54, 7135 DOI: 10.1039/C8CC01336E

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