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Issue 45, 2018
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The distinct structural preferences of tau protein repeat domains

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Abstract

The tau fibrillar structures from the brain of an Alzheimer's patient have a core with a C-shaped motif of the third and fourth repeat domains (R3–R4). Our simulations indicated that the C-shaped motif is only stable for R3–R4, while R1–R2 tends to be linear in shape. These two structural motifs appear in the most stable K18 protofilament. Heparin can further stabilize the C-shaped R3–R4 motif, but not other repeats.

Graphical abstract: The distinct structural preferences of tau protein repeat domains

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Publication details

The article was received on 13 Feb 2018, accepted on 08 May 2018 and first published on 08 May 2018


Article type: Communication
DOI: 10.1039/C8CC01263F
Citation: Chem. Commun., 2018,54, 5700-5703
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    The distinct structural preferences of tau protein repeat domains

    X. Li, X. Dong, G. Wei, M. Margittai, R. Nussinov and B. Ma, Chem. Commun., 2018, 54, 5700
    DOI: 10.1039/C8CC01263F

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