Issue 47, 2018

Inhibition of tau-derived hexapeptide aggregation and toxicity by a self-assembled cyclic d,l-α-peptide conformational inhibitor

Abstract

Aggregation and accumulation of amyloid β and tau proteins to plaques and neurofibrillary tangles are the key pathogenic events in Alzheimer's disease. Here, we studied the capability of the cyclic D,L-α-peptide CP-2 as a conformational inhibitor of different amyloids to cross-interact with tau-derived AcPHF6 peptide and inhibit its aggregation, membrane perturbation and toxicity.

Graphical abstract: Inhibition of tau-derived hexapeptide aggregation and toxicity by a self-assembled cyclic d,l-α-peptide conformational inhibitor

Supplementary files

Article information

Article type
Communication
Submitted
11 Feb 2018
Accepted
14 May 2018
First published
16 May 2018

Chem. Commun., 2018,54, 5980-5983

Inhibition of tau-derived hexapeptide aggregation and toxicity by a self-assembled cyclic D,L-α-peptide conformational inhibitor

A. Belostozky, M. Richman, E. Lisniansky, A. Tovchygrechko, J. H. Chill and S. Rahimipour, Chem. Commun., 2018, 54, 5980 DOI: 10.1039/C8CC01233D

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