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Issue 30, 2018
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Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions

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Abstract

A facile strategy for the synthesis of trifunctional molecules involving three sequential selective triazole-forming reactions is proposed. This method exploits three kinds of mechanistically different azido-type-selective cycloadditions. Three different azidophiles could be efficiently connected to a triazido platform molecule with three types of azido groups in a consecutive manner, which rendered a practical trifunctional molecule readily available.

Graphical abstract: Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions

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Publication details

The article was received on 10 Feb 2018, accepted on 02 Mar 2018 and first published on 05 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC01195H
Citation: Chem. Commun., 2018,54, 3705-3708
  • Open access: Creative Commons BY license
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    Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions

    S. Yoshida, K. Kanno, I. Kii, Y. Misawa, M. Hagiwara and T. Hosoya, Chem. Commun., 2018, 54, 3705
    DOI: 10.1039/C8CC01195H

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